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THIMEROSAL

Thimerosal is an inorganic mercury compound that is metabolized to ethylmercury and thiosalicylate and has been present since the 1930’s as a preservative in some vaccines and pharmaceutical products to prevent bacterial and fungal contamination. 

Click here to view video from the University of Calgary.
How Mercury Causes Brain Neuron Degeneration

(Requires Quicktime 4.1 or higher)

THE FACTS:

  1. Mercury is hazardous to humans. The use of a toxic poison as a preservative is undesirable, unnecessary and should be eliminated entirely.
     

  2. For decades, ethylmercury was used extensively in medical products ranging from vaccines to topical ointments as preservative and an anti-bacteriological agent.
     

  3. Manufacturers of vaccines and thimerosal, (an ethylmercury compound used in vaccines), have never conducted adequate testing on the safety of thimerosal. The FDA has never required manufacturers to conduct adequate safety testing on thimerosal and ethylmercury compounds. Current evidence suggests thimerosal is neither "safe nor effective" when used as a preservative in vaccines.
     

  4. There are over 1500 studies and papers documenting the hypoallergenicity and toxicity of thimerosal (ethylmercury) have existed for decades.
     

  5. The United States is in the midst of a tragic epidemic of autism. An analysis of the US Department of Education data from 1992-1993 in comparison to 2000-2001 indicates that there has been an average increase of 644% among all US children.  In addition, 13 states have reported an almost infinite or infinite increase in autism from 1992-1993 in comparison to 2000-2001. A review of children in US schools indicates that approximately 1 in 9 children in the US is currently disabled by the US Department of Education Statistics (see attachment).  Recent studies in the Journal of the American Medical Association and Pediatrics have confirmed the autism epidemic is real and not due to changes in diagnosis, populational changes nor is it explained by other factors.
     

  6. At the same time that the incidence of autism was growing, the number of childhood vaccines containing thimerosal was growing, increasing the amount of ethylmercury to which infants were exposed threefold.
     

  7. A growing number of scientists and researchers believe that a relationship between the increase in neurodevelopmental disorders of autism, attention deficit hyperactive disorder, and speech or language delay, and the increased use of thimerosal in vaccines is plausible and deserves more scrutiny. In 2001, the Institute of Medicine determined that such a relationship is biologically plausible, but that not enough evidence exists to support or reject this hypothesis. Recent studies have confirmed the association between the use of thimerosal and autism has moved from "biologically plausible" to a "biological certainty" (Boyd Haley).  Recent work by Dr. Mark Geier and David Geier in the Journal of American Physicians and Surgeons and Experimental Biology and Medicine have shown strong epidemiological evidence for a causal relationship between thimerosal and neurodevelopmental disorders in children.
     

  8. The FDA acted too slowly to remove ethylmercury from over-the-counter products like topical ointments and skin creams. Although an advisory committee determined that ethylmercury was unsafe in these products in 1980, a rule requiring its removal was not finalized until 1998.
     

  9. The FDA and the CDC failed in their duty to be vigilant as new vaccines containing thimerosal were approved and added to the immunization schedule. When the Hepatitis B and Haemophilus Influenzae Type b vaccines were added to the recommended schedule of childhood immunizations, the cumulative amount of ethylmercury to which children were exposed nearly tripled.
     

  10. The amount of ethylmercury to which children were exposed through vaccines prior to the 1999 announcement exceeded two safety thresholds established by the Federal Government for a closely related substance - methylmercury. While the Federal Government has established no safety threshold for ethylmercury, experts agree that the methylmercury guidelines are a good substitute. Federal health officials have conceded that the amount of thimerosal in vaccines exceeded the EPA threshold of 0.1 micrograms per kilogram of bodyweight. In fact, the amount of mercury in one dose of DTaP or Hepatitis B vaccines (25 micrograms each) exceeded this threshold many times over. Federal health officials have not conceded that this amount of thimerosal in vaccines exceeded the FDA's more relaxed threshold of 0.4 micrograms per kilogram of body weight. In most cases, however, it clearly did. As evidence of the growing concern of the adverse effects of mercury, the FDA has recently changed its permissible dose of oral methylmercury from 0.4 microgram to 0.1 micrograms per kilogram of body weight per day.
     

  11. The actions taken by the HHS to remove thimerosal from vaccines in 1999 were not sufficiently aggressive. As a result, thimerosal remained in some vaccines for an additional two years. Thimerosal remains in several vaccines and with the addition of the influenza vaccine now being recommended for infants, children are exposed to more thimerosal today than ever before.
     

  12. The CDC's failure to state a preference for thimerosal-free vaccines in 2000 and again in 2001 was an abdication of their responsibility. As a result, many children received vaccines containing thimerosal when thimerosal-free alternatives were available.
     

  13. Thimerosal should be removed from all of these vaccines. No amount of mercury is appropriate in any childhood vaccine.
     

  14. The CDC in general and the National Immunization Program in particular are conflicted in their duties to monitor the safety of vaccines, while also charged with the responsibility of purchasing vaccines for resale as well as promoting increased immunization rates.
     

  15. There is inadequate research regarding ethylmercury neurotoxicity and
    nephrotoxicity.
     

  16. There is inadequate research regarding the relationship between autism and the use of mercury-containing vaccines.
     

  17. To date, studies conducted or funded by the CDC that purportedly dispute any correlation between autism and vaccine injury have been of poor design, under-powered, and fatally flawed. The CDC's rush to support and promote such research is reflective of a philosophical conflict in looking fairly at emerging theories and clinical data related to adverse reactions from vaccinations.

    For more information please visit www.safeminds.org
     

Table A:
Summary Comparison of Characteristics
of Autism & Mercury Poisoning

Mercury Poisoning

Autism

Psychiatric Social deficits, shyness, social withdrawal Social deficits, social withdrawal, shyness
Disturbances Depression, mood swings; mask face Depressive traits, mood swings; flat affect
  Anxiety Anxiety
  Schizoid tendencies, OCD traits Schizophrenic & OCD traits; repetitiveness
  Lacks eye contact, hesitant to engage others Lack of eye contact, avoids conversation
  Irrational fears Irrational fears
  Irritability, aggression, temper tantrums Irritability, aggression, temper tantrums
  Impaired face recognition Impaired face recognition
Speech, Loss of speech, failure to develop speech Delayed language, failure to develop speech
Language & Dysarthria; articulation problems Dysarthria; articulation problems
Hearing Speech comprehension deficits Speech comprehension deficits
Deficits Verbalizing & word retrieval problems Echolalia; word use & pragmatic errors
  Sound sensitivity Sound sensitivity
  Hearing loss; deafness in very high doses Mild to profound hearing loss
  Poor performance on language IQ tests Poor performance on verbal IQ tests
Sensory Abnormal sensation in mouth & extremities Abnormal sensation in mouth & extremities
Abnormalities Sound sensitivity Sound sensitivity
  Abnormal touch sensations; touch aversion Abnormal touch sensations; touch aversion
  Vestibular abnormalities Vestibular abnormalities
Motor Disorders Involuntary jerking movements – arm flapping, ankle jerks, myoclonal jerks, choreiform movements, circling, rocking Stereotyped movements - arm flapping, jumping, circling, spinning, rocking; myoclonal jerks; choreiform movements
  Deficits in eye-hand coordination; limb apraxia; intention tremors Poor eye-hand coordination; limb apraxia; problems with intentional movements
  Gait impairment; ataxia – from incoordination & clumsiness to inability to walk, stand, or sit; loss of motor control Abnormal gait and posture, clumsiness and incoordination; difficulties sitting, lying, crawling, and walking
  Difficulty in chewing or swallowing Difficulty chewing or swallowing
  Unusual postures; toe walking Unusual postures; toe walking
Cognitive Impairments Borderline intelligence, mental retardation - some cases reversible Borderline intelligence, mental retardation - sometimes "recovered"
  Poor concentration, attention, response inhibition Poor concentration, attention, shifting attention
  Uneven performance on IQ subtests Uneven performance on IQ subtests
  Verbal IQ higher than performance IQ Verbal IQ higher than performance IQ
  Poor short term, verbal, & auditory memory Poor short term, auditory & verbal memory
  Poor visual and perceptual motor skills, impairment in simple reaction time Poor visual and perceptual motor skills, lower performance on timed tests
  Difficulty carrying out complex commands Difficulty carrying out multiple commands
  Word-comprehension difficulties Word-comprehension difficulties
  Deficits in understanding abstract ideas & symbolism; degeneration of higher mental powers Deficits in abstract thinking & symbolism, understanding other’s mental states, sequencing, planning & organizing

(iv)

Unusual Stereotyped sniffing (rats) Stereotyped, repetitive behaviors
Behaviors ADHD traits ADHD traits
  Agitation, unprovoked crying, grimacing, staring spells Agitation, unprovoked crying, grimacing, staring spells
  Sleep difficulties Sleep difficulties
  Eating disorders, feeding problems Eating disorders, feeding problems
  Self injurious behavior, e.g. head banging Self injurious behavior, e.g. head banging
Visual Poor eye contact, impaired visual fixation Poor eye contact, problems in joint attention
Impairments "Visual impairments," blindness, near-sightedness, decreased visual acuity "Visual impairments"; inaccurate/slow saccades; decreased rod functioning
  Light sensitivity, photophobia Over-sensitivity to light
  Blurred or hazy vision Blurred vision
  Constricted visual fields Not described
Physical Disturbances Increase in cerebral palsy; hyper- or hypo-tonia; abnormal reflexes; decreased muscle strength, especially upper body; incontinence; problems chewing, swallowing, salivating Increase in cerebral palsy; hyper- or hypotonia; decreased muscle strength, especially upper body; incontinence; problems chewing and swallowing
  Rashes, dermatitis/dry skin, itching; burning Rashes, dermatitis, eczema, itching
  Autonomic disturbance: excessive sweating, poor circulation, elevated heart rate Autonomic disturbance: unusual sweating, poor circulation, elevated heart rate
Gastro-intestinal Gastroenteritis, diarrhea; abdominal pain, constipation, "colitis" Diarrhea, constipation, gaseousness, abdominal discomfort, colitis
Disturbances Anorexia, weight loss, nausea, poor appetite Anorexia; feeding problems/vomiting
  Lesions of ileum & colon; increased gut permeability Leaky gut syndrome
  Inhibits dipeptidyl peptidase IV, which cleaves casomorphin Inadequate endopeptidase enzymes needed for breakdown of casein & gluten
Abnormal Biochemistry Binds -SH groups; blocks sulfate transporter in intestines, kidneys Low sulfate levels
  Has special affinity for purines & pyrimidines Purine & pyrimidine metabolism errors lead to autistic features
  Reduces availability of glutathione, needed in neurons, cells & liver to detoxify heavy metals Low levels of glutathione; decreased ability of liver to detoxify heavy metals
  Causes significant reduction in glutathione peroxidase and glutathione reductase Abnormal glutathione peroxidase activities in erythrocytes
  Disrupts mitochondrial activities, especially in brain Mitochondrial dysfunction, especially in brain
Immune Dysfunction Sensitivity due to allergic or autoimmune reactions; sensitive individuals more likely to have allergies, asthma, autoimmune-like symptoms, especially rheumatoid-like ones More likely to have allergies and asthma; familial presence of autoimmune diseases, especially rheumatoid arthritis; IgA deficiencies
  Can produce an immune response in CNS On-going immune response in CNS
  Causes brain/MBP autoantibodies Brain/MBP autoantibodies present
  Causes overproduction of Th2 subset; kills/inhibits lymphocytes, T-cells, and monocytes; decreases NK T-cell activity; induces or suppresses IFNg & IL-2 Skewed immune-cell subset in the Th2 direction; decreased responses to T-cell mitogens; reduced NK T-cell function; increased IFNg & IL-12

(v)

CNS Structural Pathology Selectively targets brain areas unable to detoxify or reduce Hg-induced oxidative stress Specific areas of brain pathology; many functions spared
  Damage to Purkinje and granular cells Damage to Purkinje and granular cells
  Accummulates in amygdala and hippocampus Pathology in amygdala and hippocampus
  Causes abnormal neuronal cytoarchitecture; disrupts neuronal migration & cell division; reduces NCAMs Neuronal disorganization; increased neuronal cell replication, increased glial cells; depressed expression of NCAMs
  Progressive microcephaly Progressive microcephaly and macrocephaly
  Brain stem defects in some cases Brain stem defects in some cases
     
Abnormalities in Neuro-chemistry Prevents presynaptic serotonin release & inhibits serotonin transport; causes calcium disruptions Decreased serotonin synthesis in children; abnormal calcium metabolism
  Alters dopamine systems; peroxidine deficiency in rats resembles mercurialism in humans Possibly high or low dopamine levels; positive response to peroxidine (lowers dopamine levels)
  Elevates epinephrine & norepinephrine levels by blocking enzyme that degrades epinephrine Elevated norepinephrine and epinephrine
  Elevates glutamate Elevated glutamate and aspartate
  Leads to cortical acetylcholine deficiency; increases muscarinic receptor density in hippocampus & cerebellum Cortical acetylcholine deficiency; reduced muscarinic receptor binding in hippocampus
  Causes demyelinating neuropathy Demyelination in brain
EEG Causes abnormal EEGs, epileptiform activity Abnormal EEGs, epileptiform activity
Abnormalities/ Causes seizures, convulsions Seizures; epilepsy
Epilepsy Causes subtle, low amplitude seizure activity Subtle, low amplitude seizure activities
Population Effects more males than females Male:female ratio estimated at 4:1
Charact-eristics At low doses, only affects those geneticially susceptible High heritability - concordance for MZ twins is 90%
  First added to childhood vaccines in 1930s First "discovered" among children born in 1930s
  Exposure levels steadily increased since 1930s with rate of vaccination, number of vaccines Prevalence of autism has steadily increased from 1 in 2000 (pre1970) to 1 in 500 (early 1990s), higher in 2000.
  Exposure occurs at 0 - 15 months; clinical silent stage means symptom emergence delayed; symptoms emerge gradually, starting with movement & sensation Symptoms emerge from 4 months to 2 years old; symptoms emerge gradually, starting with movement & sensation

The information provided on this page is for educational and informational purposes only and should not be considered legal or medical advice. NAA strongly believes that everyone should do their own research into the causes of autism spectrum disorders.


 
 

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